We overcome the problems in the production and development process continuously via gathering the technical strength of the team. We also provide customized research and development (Contract Research Organization, CRO), custom production (Contract Manufacture Organization, CMO), custom development and production (Contract Development Manufacture Organization, CDMO) and API process technology commissioned research and development services for small molecule pharmaceutical intermediates, based on advanced facilities and equipment and rich project management experience.
Owing the ability to overcome the problems of the chemical custom synthesis and process
Innovative synthesis route exploration
Process development and optimization
Process technology plan transfer
Being able to finish kilogram-level custom synthesis projects quickly
Pilot test and large-scale industrial production of key intermediates
Sustainably supply of high-quality compounds, with specifications ranging from grams to tons
The pilot platform, which can scale up and produce 1-10 kilograms per batch
Rich project management experience, to help customers achieve smooth progress from pre-clinical research and development to industrialized mass production through seamless technology docking
The production platform, which is equipped with a multi-functional production line to ensure efficient and stable production capacity
Our professional team provides a "one-stop" full-service, assisting customers to develop a complete plan to ensure compliance with requirements. Utilize rich project management experience and submit specialized knowledge, integrate all research effectively, and provide you with comprehensive strategic guidance in order to make your project succeed.
1. Lead compound discovery
Design a similar compound library based on the lead compound
Synthetic similar compound library
Pre-formulation/formulation studies for optimizing lead compounds
2. Lead compound optimization and candidate drug screening
Medicinal Chemistry/QAR Research
New drug development project integration
Drug candidate system evaluation
3. Pharmaceutical research on early phase development of new drugs
API process development research
Preparation and submission of CFDA IND documents for domestic customers
We innovate and develop new high-end pharmaceutical chemical reagents continuously, and build a library containing more than forty types of molecular building blocks and template molecular compounds with novel structures. By combining these molecular building blocks and template molecules, we can design a large number of virtual compounds rationally in order to accelerate development process.
10,000+ annual sales varieties
26,000 stock compounds with specifications ranging from gram to ton level, always maintaining a high-quality sustainable supply
20,000+ molecular blocks delivered quickly within two weeks
10,000+ tool compounds designed based on drug structure-activity relationship
100,000+ specially-designed molecular building blocks
15 core product series
More than 45 chemical product series, covering all the chemical structures commonly used in small molecule drug development
The three major test centers, located in Shanghai, Anqing and Weifang, can provide you with five services including flux detection, confirmation of unknown structures, preparation and separation, reaction heat risk assessment, and process package optimization, providing a strong guarantee for enterprise research and development.
Test center services:
a) Normal testing
Undertake conventional test projects such as HNMR, LCMS, HPLC, GC, XRPD, etc., and provide analysis and test support service for R&D enterprises (we have provided the service to more than 300 long-term cooperative customers currently).
b) Confirmation of unknown structures
Through elemental analysis, nuclear magnetic, secondary mass spectrometry, X-ray diffraction and other analytical methods, the impurities in the process route and the unknown structure of the active substance in the natural product can be confirmed.
c) Preparation and separation
For active components of the natural product, process intermediates, small-scale test products, etc., we provide preparation and separation services from milligrams to kilograms through analytical methods.
d) Reaction heat risk assessment
Perform thermal risk analysis of various reactions through RC1, ARC and other instruments, and provide corresponding HZAOP reports and SIL rating reports.
e) Process package optimization
From the perspective of the intrinsic safety of the reaction, the process package can be optimized based on safety, economy, and practicality, especially to avoid dangerous reactions rated 4 or 5 in the existing process.
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